Mounjaro is a medication taken once a week to help manage the effects of type-2 diabetes and support weight loss for patients who have a BMI of 30 or above (this can be lowered to 27 if you are suffering from a weight-related health complication).If Mounjaro is prescribed for weight loss, it’s suggested that patients take it alongside increased physical activity and a reduced-calorie diet.Who can take Mounjaro?Prescribing guidelines can differ depending on the service.For private services, Mounjaro can be prescribed for weight loss in adults that have a BMI of:30 or above27 or above if you have a weight related health problem such as stroke or hypertensionThe NHS has said that Mounjaro will be provided in a ‘phased approach’, starting with people with a BMI of 40 or more (adjusted for ethnicity) and diagnosed with four of the below weight-related health problems:Type 2 diabetes mellitusHypertensionDyslipidaemia (abnormal fat levels in the blood)Obstructive sleep apnoeaCardiovascular heart diseaseThe National Institute for Health and Care Excellence (NICE) will review - and possibly update - these guidelines in 2028.Who shouldn't take Mounjaro?The active ingredient in Mounjaro is tirzepatide. Do not take Mounjaro if you’re allergic to any of its ingredients (these can be found in its patient information leaflet). Check with your healthcare provider if Mounjaro is suitable for you if:You have diabetic retinopathy or macular oedemaYou have ever had pancreatitisYou have severe problems with food digestion or food staying in your stomach for longer than normalYou are using insulin or sulphonylurea to treat your diabetesHow does Mounjaro work?The active ingredients in Mounjaro, tirzepatide, imitates the actions of GLP-1 and GIP pathways, two hormones that are normally found in the small intestine. This results in insulin releasing from your pancreas and has the following effects:Regulating blood sugar: The hormone that raises blood sugar, glucagon, is blocked. This keeps you feeling fuller for longer.Lowering appetite: GLP-1 affects how hungry you feelSlows down digestion: Food leaves your stomach slower, encouraging you to eat smaller portionsHow do you use Mounjaro?Mounjaro is a weekly treatment, injected into your tummy, thigh or upper arm. It should be taken on the same day every week (though it can be taken at any time of day).New patients will start Mounjaro at 2.5mg, and will increase their dosage by 2.5mg until they reach 15mg. This increase is done slowly to make sure the patient can adjust to each dose and any potential side effects. It is important to take the medication as prescribed.Does Mounjaro have any side effects?As with any treatment, you may experience side effects if you use Mounjaro. Very common side effects of Mounjaro (i.e. may affect more than 1 in 10 patients) include:Nausea and vomiting (this usually goes away over time)DiarrhoeaStomach painConstipationSome patients may experience side effects during dose escalation. These may improve over time. If symptoms are severe or persistent, seek advice from your prescriber.Although it is uncommon, you must seek urgent medical attention if you start to experience the symptoms of pancreatitis:Severe abdominal pain (this may spread to the back)This may be accompanied by nausea and vomitingIf you want to learn about less common Mounjaro side effects, read the patient information leaflet for the treatment.Mounjaro FAQsWhere is Mounjaro available in the UK?Mounjaro is available in the UK as a prescription-only medicine (POM). You will not be able to access Mounjaro unless you have a prescription from your healthcare provider (following a consultation), which will involve a review of your medical history and your BMI.What happens when you stop taking Mounjaro?You should talk to your prescriber or another healthcare professional before stopping Mounjaro treatment. After stopping the treatment, some patients may notice changes such as:Changes in blood sugar levelsIncreases in appetiteWeight regainChanges in eating habits or cravingsGastrointestinal changesOther changes in how they feel, physically or emotionallyExperiences can vary between individuals.Are Mounjaro and Wegovy the same thing?Mounjaro and Wegovy are different prescription medicines. They contain different active ingredients: tirzepatide in Mounjaro and semaglutide in Wegovy. Both treatments are administered as weekly injections and may be prescribed as part of weight-management treatment. You can read more in our article about Wegovy.Referenceshttps://www.medicines.org.uk/emc/files/pil.15482.pdfhttps://pmc.ncbi.nlm.nih.gov/articles/PMC4119845/https://www.england.nhs.uk/ourwork/prevention/obesity/medicines-for-obesity/weight-management-injections/
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