Medicated sleep aids

Medicated sleep aids for the temporary relief of sleep disturbances.

Shop Nytol® medicated

Herbal sleep aids

Herbal remedies with natural active ingredients used to aid restful sleep.

Shop Nytol® herbal

Liquid sleep aids

Easy to swallow alternatives to non-prescription sleeping tablets.

Shop Nytol® liquid

Give your body clock a helping hand

If you’re experiencing sleeplessness, it can be helpful to give your body clock a little nudge back into a routine with the help of Nytol®. Nytol® sleep aids are made to help you get a good night’s sleep. 

Nytol® sleep aids

Nytol® frequently asked questions

  • What does Nytol® contain and how does it work?

    Nytol provides a variety of sleep aids to suit your needs, all of which are used to help you get a good night’s sleep:

    Nytol Original and Nytol One-A-Night  both contain diphenhydramine hydrochloride, a commonly used antihistamine. It works by blocking the normal actions of histamine, the chemical that stimulates arousal-promoting areas of the brain. This helps you to drift off into a restful, deeper sleep and works by reducing alertness and promotes that first drowsy stage of sleep.

    Nytol Herbal tablets are a traditional herbal sleeping aid and contains a blend of herbal ingredients including hops, valerian and passion flower. These ingredients have traditionally been used as sleeping aids for a peaceful night’s sleep.

    Nytol Herbal Simply Sleep One-A-Night contains a natural active ingredients called Valerian root extract which has been used for decades to induce sleep and promote calmness.

  • Is Nytol® safe to use?

    Whilst all medicines can have side effects, they’re approved on the basis of their quality, safety and efficacy. The active ingredients used in Nytol are no different and have been used for many decades. Nytol should be used in line with the instructions on pack.

  • Will I feel groggy the next day after taking Nytol®?

    A morning after effect is unlikely with a full night’s sleep (around 8 hours) and you should wake-up feeling refreshed. When using Nytol its important to make sure you follow the instructions on the pack and in the leaflet.

  • Will I get dependent on taking Nytol®?

    Over-the-counter sleep medicines such as Nytol (Diphenhydramine) are used for treating occasional sleeplessness and are unlikely to cause dependency if used according to the instructions. If symptoms persist for longer than two weeks, consult a pharmacist or GP.

  • How fast does Nytol® work?

    Nytol Original and Nytol One-A-Night should be taken at least 20 minutes before going to bed.

    Nytol Herbal products should be taken 30 minutes to 1 hour before going to bed. Nytol Herbal products should be taken continuously for 2 to 4 weeks.

  • Can I take Nytol® if I wake up in the middle of the night?

    It’s best to take Nytol before going to bed in line with the instructions on the pack and in the leaflet. However, Nytol can be taken during the night if you still have time to get a full night’s sleep (around 7 to 8 hours).

  • Can I use more than one of the Nytol® sleep aid products at once?

    It is not recommended to take more than one product in the Nytol range at the same time. We suggest using the Nytol products as directed following the instructions on the pack and in the leaflet.


¹Insomnia- NHS
²Based on sales data - to verify contact:
³Insomnia- NHS
The effects of sleep deprivation – Johns Hopkins Medicine
Sleep Hygiene Tips - Headspace
Sleep hygiene: An information guide – NHS
How to get to sleep – NHS
Meditation for sleep - Headspace

Nytol Liquid caramel flavour oral solution, Nytol One-A-Night and Nytol Original 25mg Tablets contain diphenhydramine. Aids to the relief of temporary sleep disturbances for adults. Nytol Herbal Tablets. Nytol Herbal Simply Sleep One-A-Night tablets contain Valerian root extract. Traditional herbal medicinal products for use in the temporary relief of sleep disturbances exclusively based on long-standing use as traditional remedies. Nytol Herbal Simply Sleep & Calm Elixir contains Valerian root extract. A traditional herbal medicinal product for use in temporary relief of symptoms of mild anxiety and to aid sleep, exclusively based on long-standing use as a traditional remedy. Always read the leaflet.